Effectiveness of bedtime levothyroxine intake as compared to morning levothyroxine intake in children

Effects of evening vs morning levothyroxine intake: a randomized double-blind crossover trial.

BACKGROUND Levothyroxine sodium is widely prescribed to treat primary hypothyroidism. There is consensus that levothyroxine should be taken in the morning on an empty stomach. A pilot study showed that levothyroxine intake at bedtime significantly decreased thyrotropin levels and increased free thyroxine and total triiodothyronine levels. To date, no large randomized trial investigating the bes...

Can Levothyroxine Be Taken as Evening Dose? Comparative Evaluation of Morning versus Evening Dose of Levothyroxine in Treatment of Hypothyroidism

152 drug naïve primary hypothyroid patients were divided into morning (Group 1) and evening (Group 2) dosing group and evaluated for change in biochemical profile, physical functioning and Quality of Life during the course of 12 weeks of study. At the end of 12 weeks 70 (90.90%) subjects in Group 1 and 72 (96%) in Group 2 achieved euthyroidism. On evaluation clinical symptoms and total clinical...

Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial.

CONTEXT Standard therapy for patients with primary hypothyroidism is replacement with synthetic thyroxine, which undergoes peripheral conversion to triiodothyronine, the active form of thyroid hormone. Within the lay population and in some medical communities, there is a perception that adding synthetic triiodothyronine, or liothyronine, to levothyroxine improves the symptoms of hypothyroidism ...

evaluation of administering levothyroxine in morning versus evening in sari hypothyroid patients

Massive levothyroxine ingestion.

Cavitary lesions due to pulmonary tuberculosis are very rare in infants, although these may be found in older children and adolescents [1]. We report a six-month-old girl who presented with history of recurrent episodes of respiratory infections, failure to gain weight, rapid respiration and feeding difficulty since 3 months of age. Failure to thrive, respiratory distress, clubbing and decrease...